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CAR -T Cell Therapy, How Will CAR-T Cell Therapy Make Patients Cancer Free?

Context: India’s first patient(Dr. (Col) V.K Gupta) to receive indigenous CAR-T cell therapy is now cancer-free.

About Chimeric Antigen Receptor (CAR) T Cell Therapy

  • CAR T-cell therapy is a form of cancer treatment that modifies T cells, a critical component of the immune response.
  • These T cells are extracted from the patient’s own blood.
  • In a laboratory, the T cells are genetically altered by introducing DNA to carry a special protein known as a chimeric antigen receptor (CAR).
  • This CAR enables the T cells to detect and attach to specific antigens found on the surface of cancer cells.
  • After the genetic engineering process, the modified T cells are reintroduced into the patient’s body.
  • Once administered, the CAR T cells proliferate and hone in on the cancer cells, recognizing and killing them based on the presence of the target antigen.

(CAR) T Cell Therapy

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Why is CAR T Cell Therapy Is Differ From Other Therapies?

  • Specificity: It targets only cancer cells with specific antigens, sparing most healthy cells.
  • Living Drug: Uses modified living T cells as a therapeutic agent rather than chemicals or radiation.
  • Personalization: Tailored to each patient’s immune system and cancer profile.
  • Potential for Long-term Efficacy: Might only require a single administration due to the T cells’ ability to persist and proliferate in the body.
  • Engages the Immune System: Directly utilises the body’s immune cells to fight cancer.
  • Specialised for Blood Cancers: Particularly effective for certain leukemias and lymphomas.

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About the Author

I, Sakshi Gupta, am a content writer to empower students aiming for UPSC, PSC, and other competitive exams. My objective is to provide clear, concise, and informative content that caters to your exam preparation needs. I strive to make my content not only informative but also engaging, keeping you motivated throughout your journey!

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