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First Monkeypox Death In India – Free PDF Download

What has happened?

  • India has recorded its first death of a patient who had tested positive for monkeypox.
  • A youth who had arrived in Kerala from the UAE a few days ago and died in Thrissur on Saturday (July 30), had tested positive for the infection while he was abroad, state Health Minister Veena George said on Sunday (July 31).
  • This case is new — separate from the three cases detected in Kerala earlier.
  • One of those three earlier cases has been discharged from hospital, and the other two were reported to be stable on Sunday.
  • A case of monkeypox had been detected in Delhi as well. The Delhi case was different because the patient had no history of foreign travel.
  • All the cases in Kerala, including the one in which the infected person has died, were in individuals who arrived in the state from the Middle East.

Is monkeypox now a clear disease?

  • No, it does not. The fact that the man who has died had been detected with monkeypox does not necessarily mean that he was killed by the virus.
  • There may have been other causes of death as well, which can be established only after analysis of his condition by experts.
  • “A high-level probe would be held into death as monkeypox has a very low fatality rate,’’ the Health Minister said.
  • George also said that despite having tested positive, the patient did not exhibit symptoms of the disease.
  • “The youth had no symptoms of monkeypox. He had been admitted to hospital with symptoms of encephalitis and fatigue.
  • His relatives had handed over the test result (of the test carried out in the UAE) only on Saturday,” she said.
  • George also said that despite having tested positive, the patient did not exhibit symptoms of the disease.
  • “The youth had no symptoms of monkeypox. He had been admitted to hospital with symptoms of encephalitis and fatigue.
  • His relatives had handed over the test result (of the test carried out in the UAE) only on Saturday,” she said.

How many people died from monkeypox so far?

  • The multi-country outbreak since May has made more than 20,000 people sick in about 78 countries.
  • The bulk of the deaths, however, have been in Africa, where monkeypox outbreaks have been happening for years, and where a more virulent strain of the virus is believed to be circulating.
  • In all, more than 75 people are reported dead in Africa.
  • Outside Africa, there have been only three deaths,
  • not counting the Kerala death.
  • The first monkeypox-related death outside the African continent was reported in Brazil on Friday (July 29).
  • Also on Friday, there was a death in Spain’s Valencia region, and on Saturday, a patient died in the Andalusia region of the country.
  • The two deaths in Spain are Europe’s first monkeypox-related deaths.
  • However, it is important to note that the victim in Brazil was a 41-year-old man who also suffered from lymphoma and a weakened immune system.
  • “The comorbidities aggravated his condition,” Deutsche Welle (DW) quoted the government of the Brazilian state of Minas Gerais as saying.
  • The DW report also noted that both the patients in Spain had been hospitalised with infections that had attacked the brain in the days before their deaths, and
  • That it is possible their deaths were linked to pre-existing conditions.

Are there vaccines for monkeypox?

  • There is yet no dedicated monkeypox vaccine, but vaccinations against smallpox was found to be 85% effective in preventing smallpox, a disease eradicated in 1980.
  • The vaccine, called Jynneos in the U.S., wasn’t designed to fight monkeypox, a disease that until recently was rarely seen outside of certain parts of west and central Africa.
  • Instead, it was developed, with funding from the U.S. government, as a defense against a theoretical threat: the deliberate or accidental reintroduction of smallpox.
  • In 2019, the United States Food and Drugs Administration (FDA), approved the JYNNEOS vaccine for the prevention of smallpox, monkeypox and other diseases caused by orthopoxviruses,
  • In adults 18 years of age and older and categorised as having a “high risk of infection.”

How does Jynneos work?

  • JYNNEOS, developed by Danish biotechnology company, Bavarian Nordic, contains a live vaccinia virus that does not replicate efficiently in human cells.
  • The vaccinia virus is the smallpox virus but made incapable of replicating within the body.
  • It is administered as two injections 28 days apart. The immune response takes 14 days after the second dose.
  • The evidence for JYNNEOS’ effectiveness against monkeypox rests on 22 clinical trials that tested the vaccine’s safety on 7,859 people, aged 18-80, who were administered at least one dose of the vaccine.

  • Within the last few weeks, orders have come in from dozens of countries around the globe and it is looking at whether it can operate 24-hours a day, seven days a week, to meet demand.
  • Bavarian Nordic is the world’s sole supplier of a licensed vaccine for monkeypox.
  • Before the global monkeypox outbreak, only six countries had ever placed an order for Jynneos.
  • Only two—the U.S. and Canada—had built up a meaningful stockpile.

  • The ICMR has invited tenders from local companies to develop a vaccine.
  • The Serum Institute of India said it was in talks with international partners regarding a potential vaccine but that it would take time.
  • The monkeypox virus has been isolated from a clinical specimen obtained from a patient at the National Institute of Virology (NIV) in Pune, which is part of ICMR.
  • The research is significant because it might lead to the creation of diagnostic kits and vaccinations formonkeypox infection.

Q) The Deficiency of vitamin E leads to which among the following?

  1. Soft Bones
  2. Bleeding in gums
  3. Weakness in muscles
  4. Neurological disorders

 

 

 

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